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$SEPN

Septerna, Inc. Common Stock

XNASHealth CarePharmaceutical Preparations

$40.79-7.15%$3.14Prev $43.93LIVE Full chart Live alerts
No recent price bars, the chart lights up when SEPN starts printing.

Why is SEPN down today? It is at $40.79 (-7.15%), and our scanner flagged it 58 times on unusual volume this month. See the catalyst behind the move, real-time alerts the moment SEPN spikes, and full due diligence on SEPN — key stats, earnings, dilution and insider activity. Free.

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Our scanner flagged $SEPN 58 times in the last 30 days. Create a free account to track $SEPN, build a watchlist, and get instant unusual-volume alerts, with a full day of premium now and 5 more when you verify your email, no card needed.

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Key Stats

Price & performance
Price
$40.79
Change today
-7.15%
Previous close
$43.93
52-week range
$10.91 – $51.10
Valuation & dividend
Market cap
$2.04B
Ownership & volume
Shares outstanding
46.7M
SEC · as of 2026-08-05 · 15d
Insider ownership
5.7%
DEF 14A · 2026-04-30
Institutional own.
99.9%
Total held
100.0%
Short interest
3.5M
▲ +5% vs prior · as of 2026-07-31
Days to cover
14.2d
Avg daily volume
343K
Classification
Sector
Health Care
Industry
Pharmaceutical Preparations
Exchange
XNAS
Relative volumevs this time of day
5m
0.5x
15m
0.5x
1h
0.5x
1D
0.4x

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Why is $SEPN down today?

4 alerts today2.0x RVOL

SEPN is one of today's most active names, trading on unusually heavy volume (live price and day move above). Our scanner has fired 4 unusual-volume and momentum alerts on SEPN today, peaking at 2.0x its normal volume. A move this size is almost always tied to a specific catalyst. Most of the time that is an earnings report, a guidance update, or a company announcement. If none is shown above, the release may not be in our news feed yet. It will show up here as soon as it is.

Why is $SEPN moving? →▶ Replay the moveAuto-generated from live scanner data. Not investment advice.
Trading profile⚡ Ultra-low floatShortableEasy to borrowNo SSRBorrow via Alpaca · SSR from Reg SHO 201

Insiders

Insiders selling0 buys, 11 sells last 3 months (0/15 over 12 months)
Show 12 recent transactions
InsiderActionShares% of positionOwns afterValueDate
Ra Capital Management, L.P.
Director
Sold (automatic/other)-1.49M
3.2% of company
sold 21%5.50M$63.5M
at $42.50
Aug 12, 26
Third Rock Ventures V, L.P.
Beneficial Owner (10%)
Sold (automatic/other)-147K
0.3% of company
sold 2.4%6.07M$7.4M
at $50.27
Aug 12, 26
Bhatt Elizabeth
Officer
Sold (automatic/other)-25K
0.05% of company
sold 13%174K$1.1M
at $44.00
Aug 11, 26
Bhatt Elizabeth
Officer
Other25K
0.05% of company
added 14%199K$69K
at $2.76
Aug 11, 26
Long Daniel D.
Officer
Sold (automatic/other)-3Ksold 3.3%96K$113K
at $33.98
Aug 3, 26
Long Daniel D.
Officer
Other3Kadded 3.5%100K$9K
at $2.76
Aug 3, 26
Bhatt Elizabeth
Officer
Sold (automatic/other)-4Ksold 2.2%174K$136K
at $33.99
Jul 15, 26
Bhatt Elizabeth
Officer
Other4Kadded 2.3%178K$27K
at $6.81
Jul 15, 26
Long Daniel D.
Officer
Sold (automatic/other)-3Ksold 3.3%96K$114K
at $34.10
Jul 1, 26
Long Daniel D.
Officer
Other3Kadded 3.5%100K$9K
at $2.76
Jul 1, 26
Shaikhly Samira
Officer
Sold (automatic/other)-2Ksold 73%793$77K
at $35.18
Jun 29, 26
Shaikhly Samira
Officer
Other2Kadded 100%3K$15K
at $6.81
Jun 29, 26

Recent Form-4 filings via Nasdaq. Open-market buys are the signal worth watching. Grants and automatic (10b5-1) sells are routine. “% of position” is the share of that insider’s own holding the trade moved. Not investment advice.

Dilution watch

Unavailable

We could not reach SEC EDGAR, so the dilution check did not run for $SEPN. This is not a clean result: there may be an offering, a registration or a shelf on file that we were unable to read. Check it yourself on SEC EDGAR before trading it.

$SEPN Sentiment

Neutral
Bearish59Bullish
📰 News: 2 bull · 0 bearToday: -7.1%👥 Community: 0 bull · 0 bear

Blend of news sentiment, today’s move, and community votes. Not investment advice.

$SEPN Activity

News, unusual-volume alerts, AI-trader trades and community chatter - the whole story, newest first.

Alert· 1h ago
The Watcher BOUGHT $SEPN at $40.5400 __THOTH_JSON__{"side":"buy","strategyLabel":"The Watcher · position","reason":"position entry · escalator","shares":1,"instance":"Rider","setup":"escalator"}
at $40.54
Alert· 4h ago 2.0× RVOL
SEPN hit 2.000x RVOL at 12:53 PM ET
at $41.66
Alert· 6h ago
The Watcher SOLD $SEPN at $42.2100 __THOTH_JSON__{"side":"sell","strategyLabel":"The Watcher · swing","reason":"dead_tape","shares":1,"instance":"Rider"}
at $42.21
Alert· 6h ago
The Watcher BOUGHT $SEPN at $42.5900 __THOTH_JSON__{"side":"buy","strategyLabel":"The Watcher · swing","reason":"swing entry · escalator","shares":1,"instance":"Rider","setup":"escalator"}
at $42.59
Alert· 2d ago -1.0% vs EMA
$SEPN near 200 EMA: -0.99% from 200 EMA at 2:38 PM ET
at $43.71
Alert· 2d ago 5.5× RVOL
SEPN hit 5.513x RVOL at 2:38 PM ET
at $43.71
Alert· 2d ago 5.3× RVOL
SEPN hit 5.253x RVOL at 10:04 AM ET
at $44.53
Alert· 3d ago 8.3× RVOL
SEPN hit 8.267x RVOL at 2:29 PM ET
at $44.49
Alert· 3d ago
The Watcher SOLD $SEPN at $44.0800 __THOTH_JSON__{"side":"sell","strategyLabel":"The Watcher · position","reason":"bell_flat","shares":1,"instance":"Rider"}
at $44.08
Alert· 6d ago
The Watcher BOUGHT $SEPN at $44.7900 __THOTH_JSON__{"side":"buy","strategyLabel":"The Watcher · position","reason":"position entry · breakout-daily","shares":1,"instance":"Rider","setup":"breakout-daily"}
at $44.79
Alert· 6d ago -0.7% vs EMA
$SEPN near 200 EMA: -0.70% from 200 EMA at 3:10 PM ET
at $44.41
Alert· 6d ago 2.6× RVOL
SEPN hit 2.605x RVOL at 3:10 PM ET
at $44.41
Alert· 6d ago
The Watcher SOLD $SEPN at $44.2700 __THOTH_JSON__{"side":"sell","strategyLabel":"The Watcher · position","reason":"dead_tape","shares":1,"instance":"Rider"}
at $44.27
Alert· 6d ago
The Watcher BOUGHT $SEPN at $44.6000 __THOTH_JSON__{"side":"buy","strategyLabel":"The Watcher · position","reason":"position entry · breakout-daily","shares":1,"instance":"Rider","setup":"breakout-daily"}
at $44.60
Alert· 6d ago 22.7× RVOL
SEPN hit 22.735x RVOL at 10:25 AM ET
at $44.04
Alert· 7d ago -2.0% vs EMA
$SEPN near 200 EMA: -2.03% from 200 EMA at 2:08 PM ET
at $45.30
Alert· 7d ago 5.8× RVOL
SEPN hit 5.806x RVOL at 2:08 PM ET
at $45.30
Alert· 7d ago +2.05%
$SEPN moved +2.05% in 1 min (Level 2) at 12:45 PM ET
at $45.50
Alert· 7d ago -2.2% vs EMA
$SEPN near 200 EMA: -2.20% from 200 EMA at 12:37 PM ET
at $46.00
Alert· 7d ago 33.7× RVOL
SEPN hit 33.699x RVOL at 12:37 PM ET
at $46.00
Alert· 7d ago -1.32%
$SEPN moved -1.32% in 1 min (Level 1) at 12:15 PM ET
at $45.75
Alert· 7d ago 7.5× RVOL
SEPN hit 7.518x RVOL at 12:15 PM ET
at $45.75
Alert· 8d ago +2.04%
$SEPN moved +2.04% in 1 min (Level 1) at 3:02 PM ET
at $49.02
Alert· 8d ago 2.8× RVOL
SEPN hit 2.774x RVOL at 1:30 PM ET
at $47.83
Alert· 8d ago +13.0% vs EMA
SEPN 200EMA (5m) Trending · 70 bars · L3 · +12.96% above EMA · slope +2.33%
at $47.69
News· SEC EDGAR· 10d ago
Septerna, Inc.: Q2 FY2026 results, three months to Jun 30, 2026
News· SEC EDGAR· 10d ago
Septerna, Inc.: Septerna Highlights Business Progress and Reports Second Quarter 2026 Financial Results
News· The Motley Fool· 46d ago Neutral
Septerna's Chief People Officer Sold Nearly 12,000 Company Shares. What Does That Mean for Investors?
News· SEC EDGAR· 51d ago
Septerna, Inc. filed an 8-K: Shareholder Vote
News· The Motley Fool· 51d ago Neutral
Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares?
News· SEC EDGAR· 101d ago
Septerna, Inc. filed a Quarterly report (10-Q)
News· GlobeNewswire Inc.· 172d ago Bullish
Septerna Announces Positive Phase 1 Data for SEP-631, an Oral MRGPRX2 NAM for the Treatment of Mast Cell-Driven Diseases, and Outlines Initial Phase 2 Development Strategy
News· GlobeNewswire Inc.· 268d ago Bullish
Septerna to Participate in 8th Annual Evercore Healthcare Conference

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SEPN stock FAQ

Why is $SEPN down today?

SEPN is one of today's most active names, trading on unusually heavy volume (live price and day move above). Our scanner has fired 4 unusual-volume and momentum alerts on SEPN today, peaking at 2.0x its normal volume. A move this size is almost always tied to a specific catalyst. Most of the time that is an earnings report, a guidance update, or a company announcement. If none is shown above, the release may not be in our news feed yet. It will show up here as soon as it is.

What is the SEPN stock price today?

SEPN last traded at $40.79, down 7.15% on the day. The price and chart above update live during market hours (4 AM to 8 PM ET).

Where can I see live SEPN alerts?

The SEPN Live Alerts panel on this page streams real-time unusual volume (RVOL), momentum, halt and 200-EMA alerts from our scanner the moment they fire. Our scanner has flagged SEPN 58 times in the last 30 days.

What exchange is SEPN on?

SEPN (Septerna, Inc. Common Stock) trades on XNAS, with a market cap of about $2.04B in the PHARMACEUTICAL PREPARATIONS sector.

Is SEPN good for day trading?

That depends on your strategy and risk. Day traders look for volume, volatility and a clear trend. Use the live chart, RVOL alerts and 200-EMA context on this page to judge SEPN for yourself. This is not investment advice.

Live data from TheDesperateTrader scanner. Not investment advice.