Smart Money · 13F Portfolio
TheDesperateTrader.com · latest reported equity holdings
Baker Bros. Advisors’s latest 13F equity portfolio, straight from its SEC filing on May 15, 2026. Positions are ranked by size; the ones Baker Bros. Advisors opened or added to this quarter are flagged. This is what a 13F shows: reported long U.S. equity positions as of the quarter-end. It is not the full picture and it is not advice.
New & increased · 7
1 Incyte Corporation $2.89B 16.7% of book 2 Beone Medicines Ltd. $2.61B 15.1% of book 3 Insmed Incorporated $1.21B 7.0% of book 4 Madrigal Pharmaceuticals, Inc. $1.12B 6.5% of book 5 Acadia Pharmaceuticals Inc. $955M 5.5% of book 6 Revolution Medicines, Inc. $929M 5.4% of book 7 Celcuity Inc. $904M 5.2% of book 8 Kodiak Sciences Inc. $759M 4.4% of book 9 Kymera Therapeutics, Inc. $721M 4.2% of book 10 Summit Therapeutics Inc. $690M 4.0% of book 11 Added +56% Praxis Precision Medicines, Inc. $565M 3.3% of book 12 Rhythm Pharmaceuticals, Inc. $487M 2.8% of book 13 Alkermes Plc $354M 2.0% of book 14 Added +93% Grail, Inc. $208M 1.2% of book 15 Edgewise Therapeutics, Inc. $207M 1.2% of book 16 Ionis Pharmaceuticals, Inc. $154M 0.9% of book 17 Kiniksa Pharmaceuticals International, Plc $136M 0.8% of book 18 Immunovant, Inc. $136M 0.8% of book 19 Roivant Sciences Ltd. $135M 0.8% of book 20 Ideaya Biosciences, Inc. $131M 0.8% of book 21 Arrowhead Pharmaceuticals, Inc. $125M 0.7% of book 22 Stoke Therapeutics, Inc. $109M 0.6% of book 23 Immatics N.V. $107M 0.6% of book 24 Abcellera Biologics Inc. $106M 0.6% of book 25 Abivax S.A. $98M 0.6% of book 26 Added +43% Crinetics Pharmaceuticals, Inc. $85M 0.5% of book 27 Replimune Group, Inc. $84M 0.5% of book 28 Nurix Therapeutics, Inc. $72M 0.4% of book 29 Denali Therapeutics Inc. $72M 0.4% of book 30 Dianthus Therapeutics, Inc. $72M 0.4% of book 31 Monte Rosa Therapeutics, Inc. $71M 0.4% of book 32 Structure Therapeutics Inc. $69M 0.4% of book 33 Entrada Therapeutics, Inc. $64M 0.4% of book 34 Bicycle Therapeutics Plc $51M 0.3% of book 35 Spyre Therapeutics, Inc. $50M 0.3% of book 36 Rapport Therapeutics, Inc. $48M 0.3% of book 37 Added +29% Alumis Inc. $44M 0.3% of book 38 New Mirum Pharmaceuticals, Inc. $41M 0.2% of book 39 Viridian Therapeutics, Inc. $39M 0.2% of book 40 Added +234% Enliven Therapeutics, Inc. $35M 0.2% of book 41 Prelude Therapeutics Inc. $35M 0.2% of book 42 Dbv Technologies S.A. $31M 0.2% of book 43 Design Therapeutics, Inc. $28M 0.2% of book 44 Centessa Pharmaceuticals Plc Centessa Pharmaceuticals Plc $27M 0.2% of book 45 Cytomx Therapeutics, Inc. $23M 0.1% of book 46 Jade Biosciences, Inc. $23M 0.1% of book 47 Disc Medicine, Inc. $22M 0.1% of book 48 Trimmed Immunocore Holdings Plc $22M 0.1% of book 49 Xenon Pharmaceuticals Inc. $22M 0.1% of book 50 Celldex Therapeutics, Inc. $21M 0.1% of book 51 Neurogene Inc. $20M 0.1% of book 52 New Evommune, Inc. $19M 0.1% of book 53 Trimmed Tectonic Therapeutic, Inc. $19M 0.1% of book 54 Contineum Therapeutics, Inc. $19M 0.1% of book 55 Argenx Se $18M 0.1% of book 56 Cerus Corporation $18M 0.1% of book 57 Taysha Gene Therapies, Inc. $18M 0.1% of book 58 New Aktis Oncology, Inc. $18M 0.1% of book 59 New Generate Biomedicines, Inc. $18M 0.1% of book 60 Sionna Therapeutics, Inc. $16M 0.1% of book Updated Jul 15, 8:30 PM. Sourced from SEC EDGAR 13F filings. Showing the top 60 positions by value.
$INCYIncyte Corporation$2.89B16.7% of book
$ONCBeone Medicines Ltd.$2.61B15.1% of book
$INSMInsmed Incorporated$1.21B7.0% of book
$MDGLMadrigal Pharmaceuticals, Inc.$1.12B6.5% of book
$ACADAcadia Pharmaceuticals Inc.$955M5.5% of book
$RVMDRevolution Medicines, Inc.$929M5.4% of book
$CELCCelcuity Inc.$904M5.2% of book
$KODKodiak Sciences Inc.$759M4.4% of book
$KYMRKymera Therapeutics, Inc.$721M4.2% of book
$SMMTSummit Therapeutics Inc.$690M4.0% of book
$PRAXAdded +56%Praxis Precision Medicines, Inc.$565M3.3% of book
$RYTMRhythm Pharmaceuticals, Inc.$487M2.8% of book
$ALKSAlkermes Plc$354M2.0% of book
$GRALAdded +93%Grail, Inc.$208M1.2% of book
$EWTXEdgewise Therapeutics, Inc.$207M1.2% of book
$IONSIonis Pharmaceuticals, Inc.$154M0.9% of book
$KNSAKiniksa Pharmaceuticals International, Plc$136M0.8% of book
$IMVTImmunovant, Inc.$136M0.8% of book
$ROIVRoivant Sciences Ltd.$135M0.8% of book
$IDYAIdeaya Biosciences, Inc.$131M0.8% of book
$ARWRArrowhead Pharmaceuticals, Inc.$125M0.7% of book
$STOKStoke Therapeutics, Inc.$109M0.6% of book
$IMTXImmatics N.V.$107M0.6% of book
$ABCLAbcellera Biologics Inc.$106M0.6% of book
$ABVXAbivax S.A.$98M0.6% of book
$CRNXAdded +43%Crinetics Pharmaceuticals, Inc.$85M0.5% of book
$REPLReplimune Group, Inc.$84M0.5% of book
$NRIXNurix Therapeutics, Inc.$72M0.4% of book
$DNLIDenali Therapeutics Inc.$72M0.4% of book
$DNTHDianthus Therapeutics, Inc.$72M0.4% of book
$GLUEMonte Rosa Therapeutics, Inc.$71M0.4% of book
$GPCRStructure Therapeutics Inc.$69M0.4% of book
$TRDAEntrada Therapeutics, Inc.$64M0.4% of book
$BCYCBicycle Therapeutics Plc$51M0.3% of book
$SYRESpyre Therapeutics, Inc.$50M0.3% of book
$RAPPRapport Therapeutics, Inc.$48M0.3% of book
$ALMSAdded +29%Alumis Inc.$44M0.3% of book
$MIRMNewMirum Pharmaceuticals, Inc.$41M0.2% of book
$VRDNViridian Therapeutics, Inc.$39M0.2% of book
$ELVNAdded +234%Enliven Therapeutics, Inc.$35M0.2% of book
$PRLDPrelude Therapeutics Inc.$35M0.2% of book
$DBVTDbv Technologies S.A.$31M0.2% of book
$DSGNDesign Therapeutics, Inc.$28M0.2% of book
$CTMXCytomx Therapeutics, Inc.$23M0.1% of book
$JBIOJade Biosciences, Inc.$23M0.1% of book
$IRONDisc Medicine, Inc.$22M0.1% of book
$IMCRTrimmedImmunocore Holdings Plc$22M0.1% of book
$XENEXenon Pharmaceuticals Inc.$22M0.1% of book
$CLDXCelldex Therapeutics, Inc.$21M0.1% of book
$NGNENeurogene Inc.$20M0.1% of book
$EVMNNewEvommune, Inc.$19M0.1% of book
$TECXTrimmedTectonic Therapeutic, Inc.$19M0.1% of book
$CTNMContineum Therapeutics, Inc.$19M0.1% of book
$ARGXArgenx Se$18M0.1% of book
$CERSCerus Corporation$18M0.1% of book
$TSHATaysha Gene Therapies, Inc.$18M0.1% of book
$AKTSNewAktis Oncology, Inc.$18M0.1% of book
$GENBNewGenerate Biomedicines, Inc.$18M0.1% of book
$SIONSionna Therapeutics, Inc.$16M0.1% of book